White matter lesions are considered present if hyperintense on

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replica falabella handbags In the general population the prevalence of white matter hyperintensities ranges from 11 21% in adults aged around 64 to 94% at age 82.1 2 Pathological findings in regions of white matter hyperintensity include myelin pallor, tissue rarefaction associated with loss of myelin and axons, and mild gliosis.3 4 These lesions are located in the deep white matter, typically sparing subcortical U fibres, and are often seen together with vessels affected by small vessel disease.5 The affected vessels are presumed to induce the lesions in deep white matter https://www.replicastellamccartney.com through chronic hypoperfusion of the white matter and disruption of the blood brain barrier, leading to chronic leakage of plasma into the white matter.3 6 7 White matter hyperintensities are more common and extensive in patients with cardiovascular risk factors and symptomatic cerebrovascular disease.8 White matter hyperintensities can be measured quantitatively and non invasively on large population samples and have been proposed as an intermediate marker, which could be used for the identification of new risk factors and potentially as a surrogate end point in clinical trials.9Fig 1 matter hyperintensities on magnetic resonance imaging (axial fluid attenuated inversion recovery sequence) in two 80 year old patients: (left) minor white matter hyperintensities; (right) extensive white matter hyperintensities predominating in periventricular region. White matter lesions are considered present if hyperintense on T2 weighted, fluid attenuated inversion recovery, and proton density images, without prominent hypointensity on T1 weighted imagesOpen in new tabSeveral studies have assessed the relation between white matter hyperintensities and risk of stroke, dementia, and death, with partly conflicting results. We systematically reviewed and meta analysed all published longitudinal studies that tested the association of white matter hyperintensities with risk of stroke, dementia, and death, both in the general population and in a hospital based setting.MethodsUsing predefined search terms we identified references through searches of PubMed from 1966 to 23 November 2009 (see web extra methods 1) replica falabella handbags.

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